I moved to Texas for 6 years, midlife adventure. It was pretty weird not being around any of my family. I flew home every Christmas for about 10 days and flew back twice for family weddings. The holidays were weird, but I have to say the folks I worked with were so friendly and multiples would invite me to celebrate the other holidays with their families, so I was never sitting lonely. It wasn't the same of course. I found I could survive away from them and I LOVED the adventure. My family was the only thing I missed, but I couldn't imagine living extremely far away forever now.
Plenty of people do it I know and if I was younger I might go on another temporary, extended life adventure, but we are getting too old to be apart now I think.